Table 3.
Haplotype distributions of TNF-α in athletes and their association with tendinopathy
|
TNF-α Haplotypes – 1031T>C, – 857C>T and – 308G>A |
Control | Tendinopathy | P-valuea | Adjusted OR (CI 95%) |
|---|---|---|---|---|
| N (%) | ||||
| All tendinopathy casesb | N = 270 | N = 270 | ||
| TCG | 172 (63.7) | 148 (54.8) | 0.11 | 1d |
| TCA | 15 (5.6) | 31 (11.5) | 2.65 (1.32 – 5.30) | |
| TTG | 14 (5.2) | 18 (6.7) | 1.74 (0.80 – 3.80) | |
| TTA | 4 (1.5) | 3 (1.1) | 0.79 (0.17 – 3.71) | |
| CCG | 53 (19.5) | 59 (21.8) | 1.35 (0.86 – 2.11) | |
| CCA | 8 (3.0) | 7 (2.6) | 1.03 (0.35 – 2.97) | |
| CTG | 4 (1.5) | 4 (1.5) | 1.50 (0.36 – 6.26) | |
| Patellar tendinopathyc | N = 270 | N = 124 | ||
| TCG | 172 (63.7) | 71 (57.3) | 0.10 | 1d |
| TCA | 15 (5.6) | 17 (13.7) | 3.28 (1.47 – 7.31) | |
| TTG | 14 (5.2) | 8 (6.5) | 2.09 (0.76 – 5.71) | |
| TTA | 4 (1.5) | 1 (0.8) | 0.51 (0.05 – 4.81) | |
| CCG | 53 (19.5) | 22 (17.7) | 0.59 (0.59 – 1.98) | |
| CCA | 8 (3.0) | 3 (2.4) | 0.25 (0.25 – 3.92) | |
| CTG | 4 (1.5) | 2 (1.6) | 0.30 (0.30 – 9.81) | |
| Rotator cuff tendinopathyc | N = 270 | N = 100 | ||
| TCG | 172 (63.7) | 55 (55.0) | 0.01 | 1d |
| TCA | 15 (5.6) | 13 (13.0) | 3.14 (1.36 – 7.24) | |
| TTG | 14 (5.2) | 6 (6.0) | 1.88 (0.63 – 5.00) | |
| TTA | 4 (1.5) | 0 (0.0) | - | |
| CCG | 53 (19.5) | 25 (25.0) | 1.39 (0.77 – 2.51) | |
| CCA | 8 (3.0) | 0 (0.0) | - | |
| CTG | 4 (1.5) | 1 (1.0) | 0.67 (0.07 – 6.32) | |
| Achilles tendinopathyc | N = 270 | N = 44 | ||
| TCG | 172 (63.7) | 23 (52.3) | 0.26 | 1d |
| TCA | 15 (5.6) | 5 (11.4) | 3.79 (1.14 – 12.68) | |
| TTG | 14 (5.2) | 3 (6.8) | 1.99 (0.47 – 8.38) | |
| TTA | 4 (1.5) | 1 (2.3) | 0.93 (0.09 – 9.90) | |
| CCG | 53 (19.5) | 9 (20.5) | 1.33 (0.55 – 3.23) | |
| CCA | 8 (3.0) | 3 (6.8) | 3.83 (0.86 – 17.04) | |
| CTG | 4 (1.5) | 0 (0.0) | - | |
OR Odds ratio; CI confidence interval. aP-value ≤ 0.05 was obtained through the Chi-squared Test (Pearson P-value) or Fisher’s exact test. bOR adjusted by BMI and nutritional follow-up. cOR adjusted by Age, sex, sport modality, BMI and nutritional follow-up. dReference value