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. 2021 May 13;19:206. doi: 10.1186/s12967-021-02870-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Transcriptional regulation of stemness gene in prostate cancer. a The transcription factor binding intensity on stemness genes in normal prostate tissue samples, PCa tissue samples with different Gleason grades and prostate small cell cancer tissue samples. b The main transcriptional regulators were obtained by using PCA analysis. Red and green represent the strength and weakness of transcriptional regulatory factors, respectively. c The importance of known transcriptional regulators of stemness genes in prostate cancer was obtained by using PCA analysis, The shades of blue represent the correlation between transcription factors and stemness. d Motif map of transcription factors binding to EZH2