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. 2021 May 13;20:75. doi: 10.1186/s12943-021-01361-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — CircMEMO1 Expression Was Identified to Be Significantly Downregulated in HCC Tissue and Related to Patient Prognosis. a A heatmap of differentially expressed circRNAs in our HCC tissue samples compared with paratumour DN samples is shown. b Schematic illustration of circMEMO1. c qRT-PCR revealed that circMEMO1 expression was significantly downregulated in HCC tissue samples. d The circMEMO1 level in HCC tissue samples was related to vascular invasion in HCC patients. e,f Kaplan-Meier analysis showed that the level of circMEMO1 was predictive of overall survival and DFS in HCC. g Multivariate Cox analysis revealed that the circMEMO1 level in HCC tissue was an independent prognostic factor in HCC patients