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. 2021 May 12;21:259. doi: 10.1186/s12935-021-01933-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Identification of differentially expressed genes (DEGs) among GSE75037 TCGA-LUAD dataset with the cut-off criteria of |logFC| > 1 and adj.P < 0.05. a Heatmap of 50 upregulated and 50 downregulated DEGs of GSE75037. b Heatmap of 50 upregulated and 50 downregulated DEGs of TCGA-LUAD dataset. c Volcano plot of DEGs in GSE75037. d Volcano plot of DEGs in TCGA-LUAD dataset. e The Venn diagram of genes among the two DEG lists and the two lists of co-expression genes. In total, 486 overlapping differential co-expression genes are found