Table 3.
Characteristics of the experimental groups
|
Characteristics
|
Control
|
Control + PHGG
|
NAFLD
|
NAFLD + PHGG
|
| Body weight (g) | 25.7 ± 0.5 | 25.2 ± 1.1 | 20.6 ± 0.8a | 20.8 ± 1.6a |
| Liver weight (g) | 1.17 ± 0.05 | 1.03 ± 0.08 | 1.47 ± 0.11a | 1.55 ± 0.13a |
| Liver weight (% body) | 4.45 ± 0.13 | 4.13 ± 0.32 | 7.13 ± 0.40a | 7.44 ± 0.61a |
| Aspartate aminotransferase (IU/L) | 72.0 ± 7.1 | 73.1 ± 11.9 | 133.1 ± 69.1a | 83.5 ± 24.1a,b |
| Alanine aminotransferase (IU/L) | 23.4 ± 2.9 | 20.0 ± 3.4 | 112.9 ± 77.0a | 46.3 ± 15.9a,b |
| Total cholesterol (mg/dL) | 97.7 ± 6.6 | 83.7 ± 10.8 | 359.7 ± 95.0a | 306.7 ± 26.5a |
| Triglyceride (mg/dL) | 88.9 ± 25.4 | 71.1 ± 25.1 | 16.6 ± 4.0a | 36.2 ± 25.7a,b |
| Free fatty acids (mEQ/L) | 1668 ± 257 | 1334 ± 254a | 1254 ± 201a | 1119 ± 310a |
| Glucose (mg/dL) | 70 ± 53 | 73 ± 16 | 73 ± 19 | 95 ± 32 |
Data are presented as the mean ± SD.
a
P < 0.05 significant differences compared to the control group.
b
P < 0.05 significant differences between the non-alcoholic fatty liver disease (NAFLD) group and the NAFLD + Partially hydrolyzed guar gum group. Non-alcoholic fatty liver disease group was induced by high fat diet with increased intestinal permeability. NAFLD: Non-alcoholic fatty liver disease; PHGG: Partially hydrolyzed guar gum.