TABLE 2.
Antibiotic MICs during the time course of this study
| Time point (days) | MIC (mg/liter) fora: |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| AMK | GEN | AMP | PIP | CAZ | MEM | CIP | CHL | CST | |
| P. aeruginosa | |||||||||
| 0 | 4–8 | 2–4 | >512 | 8 | 1–2 | 2–4 | 0.125–0.25 | 128 | 0.5–1 |
| 28 | 4–8 | 2–4 | >512 | 8 | 2 | 2–4 | 0.06–0.25 | NT | 0.5–1 |
| 62 | 4–8 | 2–8 | >512 | 8 | 2 | 2–4 | 0.125–1 | NT | 0.5–1 |
| 97 | 4–8 | 4–8 | >512 | 8 | 2 | 1–4 | 0.06–1 | NT | 0.5–2 |
| 118 | 4–8 | 4–8 | >512 | 8–16 | 2 | 1–2 | 0.06–0.125 | NT | 0.5–1 |
| E. asburiae/E. roggenkampii | |||||||||
| 0 | 2–4 | 2–4 | 512–>512 | 2–4 | 1–2 | 0.15–0.25 | 0.06–0.125 | 4–8 | >64 |
| 28 | 16–32 | 8 | 4–16 | 4–8 | 0.5–1 | ≤0.06 | ≤0.06 | 8–16 | 16–32 |
| 62 | 8–16 | 4–8 | 16–32 | 4–16 | 1–2 | ≤0.06 | 0.125 | 8–16 | 16–32 |
| 97 | 16–32 | 8–16 | 8–16 | 8–16 | 1–2 | ≤0.06 | 0.125–0.5 | 16 | 16–64 |
| 118 | 16–32 | 8–16 | 8–16 | 8 | 1–2 | ≤0.06 | 0.125–0.5 | 8–16 | 32–64 |
| Citrobacter spp. | |||||||||
| 0 | 2–4 | 4 | 4–8 | 2–4 | 0.5–1 | 0.015 | 0.015 | 4–8 | 0.06–0.125 |
| 28 | 2–4 | 4–8 | 8–16 | 2–4 | 0.5–1 | 0.015 | 0.015 | 4–8 | 0.125–0.25 |
| 62 | 2–8 | 4–8 | 8–16 | 8–16 | 1–2 (16–32)b | 0.015–0.03 | 0.03 | 8 | 0.125–0.25 |
| 97 | 4–8 | 2–4 | 16–32 | 8 | 2–4 | 0.03 | 0.03 | 8–16 | 0.125–0.25 |
| 118 | 4–8 | 2–4 | 16–32 | 8–16 | 1–4 | 0.03–0.06 | 0.03 | 16–32 | 0.125 |
a
MIC values are shown for the antibiotics amikacin (AMK), gentamicin (GEN), ampicillin (AMP), piperacillin (PIP), ceftazidime (CAZ), meropenem (MEM), ciprofloxacin (CIP), chloramphenicol (CHL), and colistin (CST). NT, not tested.
b
Value in parentheses represents one isolate which had consistently higher CAZ MIC values.