Maximum-likelihood phylogenetic tree based on single nucleotide polymorphisms (branch lengths are not to scale). The tree includes 1,162 E. faecium isolates from pigs (red branches, n = 71) and poultry (orange branches, n = 65), as well as human sepsis isolates (teal branches, n = 1,025). Red squares indicate isolates with the vanA operon, and blue squares indicate isolates with the vanB operon. Isolates from pigs and chickens are contained within the black square. No van operon was identified in isolates within the black square.