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. 2021 Apr 29;11:641005. doi: 10.3389/fcimb.2021.641005

Table 2a.

Early Pregnancy Vaginal Sample Characteristics According to CST Category.

CHARACTERISTIC Non-iners Lactobacillus (CST I, II, V) N = 71 Lactobacillus iners (CST III) N = 151 Diverse (CST IV) N = 214 p-value1
Gestational weeks, mean ± sd 11.5 ± 1.9 11.47 ± 2.7 11.0 ± 2.4 0.158
Read count, mean ± sd 50,053 ± 27,826 52,327 ± 26,624 40,385 ± 19,724 0.0001
pH, mean ± sd 4.61 ± 0.37 4.59 ± 0.33 4.75 ± 0.43 0.001
Nugent score, mean ± sd 1.75 ± 2.29 2.85 ± 2.67 7.19 ± 2.49 0.0001
`Nugent score 
 Normal 57 (84%) 93 (65%) 20 (10%) 0.0001
 Intermediate 5 (7%) 31 (22%) 33 (16%)
 Bacterial vaginosis 6 (9%) 20 (14%) 155 (75%)
White blood cells
 None 40 (59%) 66 (46%) 102 (49%) 0.130
 Rare 12 (18%) 41 (29%) 54 (26%)
 Few 10 (15%) 34 (24%) 44 (21%)
 Moderate 5 (7%) 3 (2%) 5 (2%)
 Many 1 (2%) 0 (0%) 3 (1%)
Chao1 diversity 69.37 ± 31.98 68.57 ± 28.25 63.58 ± 27.59 0.159
Shannon diversity 1.02 ± 0.78 1.04 ± 0.80 1.79 ± 0.65 0.0001
Cytokines (log10, mg/dL)
 Interferon-γ -0.89 ± 0.23 - 0.88 ± 0.20 - 0.30 ± 0.17 0.043
 Interleukin-6 -0.85 ± 0.27 - 0.22 ± 0.18 0.51 ± 0.15 0.0001
 Interleukin-10 -3.48 ± 0.25 -3.69 ± 0.20 -2.96 ± 0.14 0.005
 TNF-α -2.54 ± 0.26 - 2.19 ± 0.18 -0.89 ± 0.13 0.0001
C-reactive protein (log10, mg/dL) -10.6 ± 0.19 -9.8 ± 0.16 -8.7 ± 0.12 0.0001

1p-value for t-test (continuous variables) or Fisher’s exact or Chi-square test (categorical variables); bold indicates statistical significance for α = 0.05.