Table 2a.
CHARACTERISTIC | Non-iners Lactobacillus (CST I, II, V) N = 71 | Lactobacillus iners (CST III) N = 151 | Diverse (CST IV) N = 214 | p-value1 |
---|---|---|---|---|
Gestational weeks, mean ± sd | 11.5 ± 1.9 | 11.47 ± 2.7 | 11.0 ± 2.4 | 0.158 |
Read count, mean ± sd | 50,053 ± 27,826 | 52,327 ± 26,624 | 40,385 ± 19,724 | 0.0001 |
pH, mean ± sd | 4.61 ± 0.37 | 4.59 ± 0.33 | 4.75 ± 0.43 | 0.001 |
Nugent score, mean ± sd | 1.75 ± 2.29 | 2.85 ± 2.67 | 7.19 ± 2.49 | 0.0001 |
`Nugent score | ||||
Normal | 57 (84%) | 93 (65%) | 20 (10%) | 0.0001 |
Intermediate | 5 (7%) | 31 (22%) | 33 (16%) | |
Bacterial vaginosis | 6 (9%) | 20 (14%) | 155 (75%) | |
White blood cells | ||||
None | 40 (59%) | 66 (46%) | 102 (49%) | 0.130 |
Rare | 12 (18%) | 41 (29%) | 54 (26%) | |
Few | 10 (15%) | 34 (24%) | 44 (21%) | |
Moderate | 5 (7%) | 3 (2%) | 5 (2%) | |
Many | 1 (2%) | 0 (0%) | 3 (1%) | |
Chao1 diversity | 69.37 ± 31.98 | 68.57 ± 28.25 | 63.58 ± 27.59 | 0.159 |
Shannon diversity | 1.02 ± 0.78 | 1.04 ± 0.80 | 1.79 ± 0.65 | 0.0001 |
Cytokines (log10, mg/dL) | ||||
Interferon-γ | -0.89 ± 0.23 | - 0.88 ± 0.20 | - 0.30 ± 0.17 | 0.043 |
Interleukin-6 | -0.85 ± 0.27 | - 0.22 ± 0.18 | 0.51 ± 0.15 | 0.0001 |
Interleukin-10 | -3.48 ± 0.25 | -3.69 ± 0.20 | -2.96 ± 0.14 | 0.005 |
TNF-α | -2.54 ± 0.26 | - 2.19 ± 0.18 | -0.89 ± 0.13 | 0.0001 |
C-reactive protein (log10, mg/dL) | -10.6 ± 0.19 | -9.8 ± 0.16 | -8.7 ± 0.12 | 0.0001 |
1p-value for t-test (continuous variables) or Fisher’s exact or Chi-square test (categorical variables); bold indicates statistical significance for α = 0.05.