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. Author manuscript; available in PMC: 2022 Feb 5.
Published in final edited form as: J Org Chem. 2021 Jan 21;86(3):3008–3016. doi: 10.1021/acs.joc.0c03021

Scheme 1.

Scheme 1.

Important Experimental Results Obtained by Ludwig et al.,32 Showing (A) the Mechanistic Probe Intermediate (19) and (B) Differences in Reactivity at High and Low Temperatures