Fig. (5).

(A) Representative photographs and (B) gross observations of gallbladders exhibit that fasting gallbladder volumes are significantly enlarged in CCK knockout mice compared with CCK wild-type mice. (C) Postprandial gallbladder sizes in response to the high fat meal. Duodenal infusion of corn oil could stimulate the release of CCK from the upper part of small intestine. As a result, the secreted CCK induces gallbladder emptying in CCK wild-type mice but not in CCK knockout mice. These results indicate that gallbladder contractile function is impaired in CCK knockout mice. Reprinted, with permission, from Ref. [65].