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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: Curr Med Chem. 2019;26(19):3407–3423. doi: 10.2174/0929867324666170619104801

Fig. (7).

Fig. (7).

Small intestinal transit rates in CCK-1R wild-type mice (top panel) and knockout mice (bottom panel) on chow or fed the lithogenic diet for 14 days as analyzed by the distribution of radioactivity at 30 minutes along the small intestine following intraduodenal instillation of [3H]sitostanol dissolved in medium-chain triglyceride [96]. Each bar is the mean percentage of radioactivity in each segment. Segments 1 and 20 represent evenly divided segments from the most proximal to the distal part of the small intestine. (A) Arrows show the geometric center that is significantly (P<0.001) shorter in chow-fed CCK-1R knockout mice, indicating significantly slower small intestinal transit times (geometric center=7.8±0.8) compared with the wild-type mice (geometric center=10.8±1.0). (B) Under conditions of feeding lithogenic diet, CCK-1R knockout mice continue to display significantly slower small intestinal transit times (geometric center=9.1±1.5) than the wild-type mice (geometric center=13.3±2.0). Reprinted, with permission, from Ref. [45].