Skip to main content
. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: Adv Exp Med Biol. 2020;1276:105–136. doi: 10.1007/978-981-15-6082-8_8

Fig. 8.2.

Fig. 8.2

This diagram of the hepatocyte shows the ABCG5/G8-dependent (red solid lines) and the ABCG5/G8-independent (red dashed lines) pathways for biliary cholesterol (Ch) secretion, as well as the ABCB4 and ABCB11 transporters for biliary phospholipid (PL) and bile salt (BS) secretion, respectively. Abbreviations: ABC ATP-binding cassette (transporter), ACAT acyl-coenzyme A:cholesterol acyltransferase, CMR chylomicron remnants, CMRR CMR receptor, CYP7A1 cholesterol 7-α-hydroxylase, CYP27A1 sterol 27-hydroxylase, HDL high-density lipoprotein, HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase, LDL low-density lipoprotein, LDLR LDL receptor, SR-BI scavenger receptor class B type I, i.e., HDL receptor, VLDL very-low-density lipoprotein