Fig. 8.4.

The reverse cholesterol transport through the classical biliary route to the bile as secreted by ABCG5/G8 on the canalicular membrane of hepatocytes. The reverse cholesterol transport in the hepatocytes is shown in red lines with arrows indicating the direction of transport. Abbreviations: ABC ATP-binding cassette (transporter), ACAT2 acyl-coenzyme A:cholesterol acyltransferase isoform 2, CYP7A1 cholesterol 7-α-hydroxylase, CYP27A1 sterol 27-hydroxylase, HDL high-density lipoprotein, HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase, LDL low-density lipoprotein, SR-BI scavenger receptor class B type I, i.e., HDL receptor, VLDL very-low-density lipoprotein