Table 2.

Set of 35 6-hydroxybenzofuran-5-carboxylic acid inhibitors (34 new analogs and I-C11 as 478) [23]

Compound	R1	R2	R3	R4	IC50, μM
478		H	H	H	4.50
479		H	H	H	3.22
480		H	H	H	1.49
481		H	H	H	0.56
482		H	H	H	0.71
483		H	H	H	3.84
486		H	H	Me	4.86
491		H	H	H	3.10
492		H	H	H	0.77
495		H	H	H	0.91
496		H	H	H	2.21
499		H	H	H	2.64
522		Me	H	H	0.41
523		Me	H	H	1.11
524		Me	H	H	0.64
525		Me	H	H	0.38
526		Me	H	H	0.27
527		Me	H	H	3.44
528		Me	H	H	0.90
529		Me	H	H	1.18
530		Me	H	H	1.35
531		Me	H	H	2.01
532		Me	H	H	1.80
569		H	Me	H	6.20
577		H	Me	H	2.35
584		MeO	H	H	0.34
586		MeO	H	H	0.34
604		H	Me	H	5.02
609		H	Me	H	0.65
610		Me	H	H	0.97
611		H	H	H	0.74
612		H	Me	H	0.65
619		Me	H	H	0.48
630		H	Me	H	0.52
636		H	Me	H	0.61