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. 2021 May 13;17(5):e1009516. doi: 10.1371/journal.pgen.1009516

Fig 6. Comparison of RNA editing ratios at coding sites among Adar mutant mice.

Fig 6

(A, B) The editing ratio at each coding site in Blcap and Azin1 genes (A) and at the indicated sites of serotonin Htr2c gene (B), which encodes 5-HT2CR, was quantified by Ion S5 sequencing using RNA isolated from indicated organs of wild-type (Adar1 p110+/+ Adar2+/+), Adar1 p110–specific KO (Adar1 p110-/- Adar2+/+), Adar2 KO (Adar1 p110+/+ Adar2-/-), and Adar1 p110/Adar2 double KO (Adar1 p110-/- Adar2-/-) mice at post-natal day 0 (P0). Values are displayed as the mean ± SEM (n = 3 mice for each group; Student’s t-test, *p < 0.05, **p < 0.01, ***p < 0.001, N.S., not significant).