Table 5.
Correlation of serum procalcitonin and tracheal aspirate results with ventilator-associated pneumonia diagnostic algorithms
| Criteria | Serum Procalcitonin Level, ng/mL | Kappa (ĸ) index, agreement level a (p-Value) |
Tracheal Culture | Kappa (ĸ) index, agreement level a (p-Value) |
|||||
|---|---|---|---|---|---|---|---|---|---|
| < 0.25 | 0.25–0.5 | > 0.5 | Total | Positive | Negative | Total | |||
| Johanson, n (%) | |||||||||
| Positive | 10 (15.4) | 9 (13.8) | 46 (70.8) | 65 |
0.47, moderate (< 0.001) |
61 (93.8) | 4 (6.2) | 65 |
0.579, moderate (< 0.001) |
| Negative | 18 (90) | 0 | 2 (10) | 20 | 8 (40) | 12 (60) | 20 | ||
| Total | 28 (32.9) | 9 (10.6) | 48 (56.5) | 85 (100) | 69 (81.2) | 16 (18.8) | 85 (100) | ||
| CDC/NHSN, n (%) | |||||||||
| Positive | 26 (31.3) | 10 (12.0) | 47 (56.6) | 83 |
0.06, slight (0.58) |
67 (80.7) | 16 (19.3) | 83 |
0.04, slight (0.49) |
| Negative | 2 (100) | 0 | 0 | 2 | 2 (100) | 0 | 2 | ||
| Total | 28 (32.9) | 10 (11.8) | 47 (55.3) | 85 (100) | 69 (81.2) | 16 (18.8) | 85 (100) | ||
| CPIS, n (%) | |||||||||
| Positive | 11 (17.5) | 8 (12.7) | 44 (69.8) | 63 |
0.42, moderate (< 0.001) |
61 (96.8) | 2 (3.2) | 63 |
0.663, substantial (< 0.001) |
| Negative | 17 (77.3) | 1 (4.5) | 4 (18.2) | 22 | 8 (36.4) | 14 (63.6) | 22 | ||
| Total | 28 (32.9) | 9 (10.6) | 48 (56.5) | 85 (100) | 69 (81.2) | 16 (18.8) | 85 (100) | ||
CDC/NHSN: centers for disease control and prevention national health safety network; CPIS: Clinical Pulmonary Infection Score, HELICS: Hospital in Europe Link for Infection Control through Surveillance
aAgreement based on score: ≤ 0 (no agreement); 0.01–0.20 (slight); 0.21–0.40 (fair); 0.41– 0.60 (moderate); 0.61–0.80 (substantial); and 0.81–1.00 (almost perfect agreement)