Table 2.
Baseline Characteristics and In-Hospital Outcomes of Patients Above 75, or Patients with Steroid Treatments Admitted with COVID-19 With and Without Convalescent Plasma Therapy
| All hospitalizations | Propensity-matched hospitalizations | |||||
|---|---|---|---|---|---|---|
| Patients above 75 years old | Without convalescent plasma (n = 2766) | With convalescent plasma (n = 336) | p value | Without convalescent plasma (n = 274) | With convalescent plasma (n = 274) | p value |
| Age, (mean, SD), year | 83.0 (5.0) | 82.6 (5.1) | 0.20 | 83.1 (4.8) | 82.8 (5.1) | 0.44 |
| Male, n (%) | 1274 (46.1) | 176 (52.4) | 0.033 | 142 (51.8) | 141 (51.5) | 1.00 |
| Hypertension, n (%) | 1271 (46.0) | 153 (45.5) | 0.93 | 127 (46.4) | 128 (46.7) | 1.00 |
| Diabetes mellitus, n (%) | 681 (24.6) | 69 (20.5) | 0.11 | 61 (22.3) | 61 (22.3) | 1.00 |
| Heart failure, n (%) | 368 (13.3) | 39 (11.6) | 0.43 | 32 (11.7) | 32 (11.7) | 1.00 |
| Oxygen saturation, (median [IQR]) | 90.0 [80.0, 92.0] | 86.0 [73.8, 90.0] | <0.001 | 86.0 [76.0, 90.0] | 86.5 [76.3, 90.0] | 0.66 |
| Therapeutic anticoagulation during hospitalization, n (%) | 1056 (38.2) | 186 (55.4) | <0.001 | 138 (50.4) | 149 (54.4) | 0.39 |
| Steroid during hospitalization, n (%) | 1302 (47.1) | 296 (88.1) | <0.001 | 242 (88.3) | 241 (88.0) | 1.00 |
| ICU admission | 465 (16.8) | 97 (28.9) | <0.001 | 69 (25.2) | 75 (27.4) | 0.63 |
| Endotracheal intubation, n (%) | 334 (12.1) | 66 (19.6) | <0.001 | 48 (17.5) | 49 (17.9) | 1.00 |
| In-hospital death, n (%) | 1054 (38.1) | 132 (39.3) | 0.72 | 124 (45.3) | 108 (39.4) | 0.20 |
| Acute kidney injury, n (%) | 933 (33.9) | 118 (35.1) | 0.69 | 98 (35.8) | 92 (33.6) | 0.65 |
| Patients with steroid treatments | Without convalescent plasma (n = 3802) | With convalescent plasma (n = 949) | p value | Without convalescent plasma (n = 816) | With convalescent plasma (n = 816) | p value |
| Age, (mean, SD), year | 66.8 (15.4) | 65.2 (16.1) | 0.005 | 64.9 (15.6) | 64.8 (16.1) | 0.97 |
| Male, n (%) | 2106 (55.4) | 573 (60.4) | 0.006 | 486 (59.6) | 489 (59.9) | 0.92 |
| Hypertension, n (%) | 1419 (37.3) | 324 (34.1) | 0.075 | 276 (33.8) | 283 (34.7) | 0.75 |
| Diabetes mellitus, n (%) | 921 (24.2) | 186 (19.6) | 0.003 | 158 (19.4) | 166 (20.3) | 0.66 |
| Heart failure, n (%) | 341 (9.0) | 67 (7.1) | 0.07 | 54 (6.6) | 56 (6.9) | 0.92 |
| Oxygen saturation, (median [IQR]) | 78.0 [63.0, 87.0] | 73.0 [50.0, 84.0] | <0.001 | 72.0 [46.3, 85.0] | 73.0 [51.3, 83.8] | 0.79 |
| Therapeutic anticoagulation during hospitalization, n (%) | 1438 (37.8) | 438 (46.2) | <0.001 | 333 (40.8) | 354 (43.4) | 0.32 |
| ICU admission | 1072 (28.2) | 314 (33.1) | 0.003 | 260 (31.9) | 259 (31.7) | 1.00 |
| Endotracheal intubation, n (%) | 718 (18.9) | 203 (21.4) | 0.089 | 170 (20.8) | 167 (20.5) | 0.90 |
| In-hospital death, n (%) | 1050 (27.6) | 250 (26.3) | 0.46 | 205 (25.1) | 217 (26.6) | 0.53 |
| Acute kidney injury, n (%) | 1182 (31.1) | 280 (29.5) | 0.35 | 226 (27.7) | 231 (28.3) | 0.83 |
ICU intensive care unit, SD standard deviation