Figure 1.

FG-4592 attenuated I/R-induced AKI. (A) Schematic diagram of the experimental design. In brief, mice were administrated with FG-4592 or vehicle before performing ischemia/reperfusion injury. And the mice were sacrificed at 48 h after disease induction. (B) Serum creatinine and BUN levels. (C) Representative images of PAS staining of kidneys (×400). (D) Tubular injury score in mice. (E) Western blot analysis of KIM-1 in renal cortex tissue lysates. n = 6 mice per group. Data are presented as mean ± SD, **p < .01 vs. I/RI + NC mice, #p < .05 vs. sham mice, ANOVA followed by Bonferroni correction.