Table 1. Residue range and number for the subdomains and functionally important sites of the RdRP.
RdRP subdomains | Residue Range |
Finger 1 (FD1) | 398–581 |
Finger 2 (FD2) | 621–679 |
Palm (PD) | 582–627 / 688–815 |
Thumb (TD) | 816–919 |
Functionally important sites | Residue name and number |
Catalytic site | TRP 617, CYS 622, SER 759, ASP 760, ASP 761, CYS 813 |
Primer binding | SER 759, ASP 760, ASP 761, CYS 813, SER 814, GLN 815 |
Template binding | LYS 500, SER 501, ASN 507 |
Inhibitor binding | LYS 551, ARG 553, ARG 555 |