Table 2.
Multivariable Analysis: Chance of High Hematocrit for Different Determinants
| Hematocrit > 0.50 L/L, crude OR (95% CI) | Adjusted OR (95% CI)b | Hematocrit > 0.52 L/L, crude OR (95%CI) | Adjusted OR (95% CI)b | |
|---|---|---|---|---|
| Tobacco use | 2.2 (1.6–3.3) | 2.0 (1.3–3.0) | 3.2 (1.7–6.2) | 2.7 (1.3–5.5) |
| Positive medical historya | 2.5 (1.4–4.4) | 2.0(1.1–3.8) | 5.3 (2.3–12.3) | 4.6 (1.9–11.2) |
| Age at initiation | ||||
| <18 | ref | ref | ref | ref |
| 18–30 | 2.5 (1.4–4.4) | 1.5(0.8–2.9) | 3.2 (1.0–9.9) | 1.9 (0.5–7.0) |
| 30–40 | 3.9 (2.0–7.5) | 1.9 (0.9–4.0) | 5.7 (1.7–19.4) | 2.7 (0.6–11.3) |
| 40–50 | 5.9 (2.8–12.3) | 3.1 (1.4–7.2) | 10.3 (2.8–38.8) | 4.9 (1.1–22.5) |
| ≥50 | 2.6 (0.8–8.6) | 1.2 (0.3–4.5) | 2.9 (0.3–26.4) | 1.1 (0.1–13.5) |
| BMI | ||||
| ≤18.5 | 0.4 (0.2–1.2) | 0.6 (0.2–1.9) | n/a | n/a |
| 18.5–25 | ref | ref | ref | ref |
| 25–30 | 3.4 (2.1–5.5) | 3.0 (1.8–5.1) | 5.3 (2.3–12.3) | 4.3 (1.7–10.8) |
| ≥30 | 3.7 (2.2–6.2) | 3.1 (1.7–5.6) | 6.1 (2.5–14.9) | 4.6 (1.7–12.3) |
| Route of testosterone | ||||
| T gel | ref | ref | ref | ref |
| Short-acting im | 1.1 (0.7–1.6) | 1.1 (0.7–1.7) | 1.5 (0.7–3.4) | 1.5 (0.6–3.7) |
| Long-acting im | 2.9 (1.7–5.0) | 3.1 (1.7–5.6) | 1.0 (0.3–3.4) | 1.3 (0.4–5.0) |
| Oral T | 0.6 (0.2–1.6) | 1.3 (0.4–3.7) | 0.2 (0.1–2.4) | 0.5 (0.1–5.6) |
| Unknown | 1.2 (0.8–1.7) | 1.9 (1.3–2.8) | 1.8 (0.9–3.8) | 2.9 (1.3–6.6) |
| Testosterone levels | ||||
| 0–10 nmol/L | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) | 0.2 (0.1–0.4) | 0.1 (0.1–0.4) |
| 10–20 nmol/L | ref | ref | ref | ref |
| 20–30 nmol/L | 1.3 (0.9–1.8) | 1.3 (0.9–1.8) | 1.3 (0.7–2.5) | 1.4 (0.7–2.7) |
| >30 nmol/L | 1.4 (1.0–1.9) | 1.5 (1.1–1.8) | 1.4 (0.7–2.5) | 1.6 (0.8–3.0) |
Abbreviations: BMI, body mass index; im, intramuscular; n/a, no data available; OR, odds ratio; T, testosterone.
a Chronic obstructive pulmonary disease/asthma, sleep apnea, chronic bronchitis, polycythemia vera
b Adjusted for all other determinants