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. 2021 Mar 27;41(5):389–403. doi: 10.1002/cac2.12137

FIGURE 6.

FIGURE 6

GFRAL is expressed in prostate cancer cells and the surrounding stromal fibroblasts. A. A representative image of hematoxylin and eosin staining of a high‐grade tumor. B. GFRAL immunostaining shows that GFRAL was predominantly expressed in the cytoplasm and membrane of cancer cells and stromal fibroblasts (arrow). C. The association of GFRAL expression with neoadjuvant treatment. Of the 19 patients, 10 did not receive neoadjuvant treatment (None), and 9 received NEO therapy. The GFRAL staining level in stromal fibroblasts was lower in the NEO group than in the None group (P = 0.017). Abbreviations: None, not receive neoadjuvant treatment; NEO, neoadjuvant androgen deprivation therapy and/or chemotherapy.