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. 2021 Apr 29;8:670940. doi: 10.3389/fmolb.2021.670940

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Copyright © 2021 Hunt, Tamanaha, Bonanno, Cantor and Tanner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Comparison of fully-complementary g1B/D/H/V guides to partially-complementary (g1 not complementary to t1) g1A/C/G/T guides. (B) A heatmap comparing the average activity of all g1-t1 combinations with single- and double-stranded substrates. (C) Comparing partially-complementary g1C and g1T guides to the same population of fully-complementary g1R guides. Boxplots have been annotated for statistical significance between relevant groups using the following labels: ns (not significant) for p > 0.05; ^∗∗ for p ≤ 0.01; and ^**** for p ≤ 0.0001.