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AKT structure. The three AKT isoforms (AKT1/2/3) are kinases sharing a common structure, which consists of an N-terminus pleckstrin homology (PH) domain, a large central kinase domain and a C-terminus regulatory domain (RD). The main phosphorylation sites of AKT are threonine and serine residues located in the kinase domain (T305/T308/T309) and in the regulatory domain (S472/473/474), respectively.
