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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: Science. 2021 Feb 26;371(6532):eabb8255. doi: 10.1126/science.abb8255

Fig. 4. Tau-related challenges and needs.

Fig. 4.

In principle, several of the trailblazing discoveries reviewed here could lead to the development of better treatments for AD and other tauopathies. However, many efforts to develop treatments for brain diseases have failed, in large part because of an inadequate understanding of the pathobiology of these complex disorders and, perhaps, because too many fundamental knowledge gaps, alternative interpretations of data, and methodological complexities did not receive the attention they deserved. Addressing the scientific knowledge gaps and technological challenges highlighted in this Review could accelerate and enable the development of truly impactful tau-related diagnostics and therapeutics. PTM, posttranslational modification.