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. 2021 Apr 20;10:e61138. doi: 10.7554/eLife.61138

Table 2. The top 25 GO terms associated with DE genes from old vs. old AAV-Kl treated mice.

Term P-value Adjusted P-value Odds Ratio Combined Score
negative regulation of transcription from RNA polymerase II promoter in response to stress (GO:0097201) 0.000331 0.09424241 13.1472045 105.3348
regulation of protein modification by small protein conjugation or removal (GO:1903320) 0.00023 0.07658759 9.8657932 82.66108
response to unfolded protein (GO:0006986) 5.3E-06 0.00896227 5.72185053 69.50717
response to chemokine (GO:1990868) 0.006044 0.307829996 13.1300353 67.07703
response to granulocyte macrophage colony-stimulating factor (GO:0097012) 0.006044 0.307829996 13.1300353 67.07703
regulation of histone deacetylase activity (GO:1901725) 0.006044 0.307829996 13.1300353 67.07703
negative regulation of vasculature development (GO:1901343) 0.006044 0.307829996 13.1300353 67.07703
regulation of respiratory system process (GO:0044065) 0.006044 0.307829996 13.1300353 67.07703
negative regulation of myeloid cell apoptotic process (GO:0033033) 0.006044 0.307829996 13.1300353 67.07703
cellular response to granulocyte macrophage colony-stimulating factor stimulus (GO:0097011) 0.006044 0.307829996 13.1300353 67.07703
regulation of microtubule nucleation (GO:0010968) 0.006044 0.307829996 13.1300353 67.07703
cellular response to chemokine (GO:1990869) 0.006044 0.307829996 13.1300353 67.07703
RNA stabilization (GO:0043489) 0.000787 0.169749244 7.17396343 51.27482
chaperone-mediated protein complex assembly (GO:0051131) 0.000787 0.169749244 7.17396343 51.27482
mitochondrial translation (GO:0032543) 1.36E-06 0.004970703 3.63077317 49.05655
3'-UTR-mediated mRNA destabilization (GO:0061158) 0.003735 0.29111327 8.75813296 48.95746
primary miRNA processing (GO:0031053) 0.003735 0.29111327 8.75813296 48.95746
cellular response to leucine starvation (GO:1990253) 0.003735 0.29111327 8.75813296 48.95746
endothelial tube morphogenesis (GO:0061154) 0.003735 0.29111327 8.75813296 48.95746
negative regulation of inclusion body assembly (GO:0090084) 0.003735 0.29111327 8.75813296 48.95746
mitochondrial gene expression (GO:0140053) 4.92E-05 0.025776303 4.79736196 47.58752
regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213) 0.010022 0.41209955 9.84699647 45.32527
mitochondrial electron transport, ubiquinol to cytochrome c (GO:0006122) 0.002072 0.281362729 7.30242982 45.12396
mitochondrial translational elongation (GO:0070125) 8.63E-06 0.00896227 3.6976622 43.11427
mitochondrial translational termination (GO:0070126) 1.22E-05 0.00896227 3.59162667 40.63