Table 3. Top 25 GO terms associated with DE genes from oldest-old vs. oldest-old AAV-Kl-treated mice.
| Klotho mediated Bi-phasic KEGG Pathways Gene Expression | ||||||||
|---|---|---|---|---|---|---|---|---|
| Old + log2FC | Oldest-Old + log2FC | |||||||
| Regulation of actin cytoskeleton | F2 | -1.92627 | Bcarl | 0.40772 | Rras | 0.30578 | Rhoa | 0.08657 |
| Kng2 | -1.09411 | Arpc3 | 0.22899 | Pik3rl | -0.94428 | Itga5 | 0.30051 | |
| Diaph2 | 0.25901 | Brkl | 0.17587 | Rafl | -0.19865 | Hras | 0.22869 | |
| Itga9 | 0.39371 | Arhgap35 | -0.24801 | Pfn1 | 0.19127 | |||
| Pdgfrb | -0.35413 | Pip4k2c | -0.16982 | Pfn2 | -0.20196 | |||
| ltgax | 1.6131 | Apc2 | -0.52877 | |||||
| Arpc2 | 0.1243 | Cdc42 | 0.11714 | |||||
| cGMP-PKG signaling | F2 | -1.9263 | Dgke | -0.3491 | Pik3rl | -0.94428 | Cyth1 | 0.13784 |
| Lpar3 | 1.82228 | Pdgfrb | -0.35413 | Rafl | -0.19865 | Rhoa | 0.08657 | |
| Adcy9 | -0.20643 | Dnm3 | -0.54357 | Hras | 0.22869 | |||
| Rras | 0.30578 | Pla224e | -0.25837 | |||||
| Sphingolipid signaling pathway | Kng2 | -1.0941 | Sgppl | -0.1274 | Pik3rl | -0.94428 | Hras | 0.22869 |
| Map3k5 | 0.27371 | Rafl | -0.19865 | |||||
| Ctsd | 0.17911 | Rhoa | 0.08657 | |||||