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. 2021 Apr 29;11:632834. doi: 10.3389/fonc.2021.632834

Table 3.

circRNAs as biomarkers for the diagnosis and prognosis of CRC.

CircRNAs Targeted miRNA Regulatory Role of circRNA on miRNA The expression of circRNA Potential biomarkers Reference
circSMARCC1 miR-140-3p Negative Therapeutic (1)
hsa-miR-6833- (2)
circ-PNN 3p/hsa-let-7i-3p/hsa-miR-1301-3p Negative Diagnostic
circRNA_101951 / / Prognostic/Therapeutic (3)
circPTK2 / / Diagnostic/Therapeutic (4)
circCAMSAP1 miR-328-5p Negative Prognostic/Diagnostic/Therapeutic (5)
circ-0004771 / / Diagnostic (6)
circ_0000338 / / Therapeutic (7)
hsa_circ_0082182
Diagnostic (8)
hsa_circ_0000370 hsa_circ_0035445 / / ↑↓
circ-CCDC66  (9)
 circ-ABCC1  circ-STIL / / ↓↓ Diagnostic
circ-ITGA7 miR-3187-3p Negative Diagnostic/Therapeutic (10)
hsa_circ_0004585 Multiple / Diagnostic/Therapeutic (11)
hsa_circ_0142527 / / Diagnostic (12)
circVAPA miR-101 Negative Diagnostic/Therapeutic (13)
circDDX17 hsa-miR-21-5p Negative Diagnostic/Therapeutic (14)
circ_0026344 miR-21/miR-31 Negative Prognostic (15)
circHIPK3 miR-7 Negative Prognostic/Therapeutic (16)
hsa_circ_0007534 / / Diagnostic/Prognostic (17)
circRNA0003906 / / Diagnostic/Therapeutic (18)
hsa_circRNA_103809  / / Diagnostic (19)
 hsa_circRNA_104700
circRNA_001569 miR-145 Negative Therapeutic (20)
hsa_circ_0005075 / / Diagnostic/Therapeutic (21)
hsa_circ_0020397 miR-138 Negative Therapeutic (22)
hsa_circ_0136666 miR-136 Negative Therapeutic (23)
hsa_circ_0000523 miR-31 Negative Therapeutic (24)
has_circ_0055625 miR‐106b‐5p Negative Therapeutic/Prognostic (25)
circ_104916 / / Therapeutic/Prognostic (26)
hsa_circ_0000423 / / Therapeutic/Prognostic (27)
hsa_circ_0001649 / / Diagnostic (28)
hsa_circ_0000567 / / Diagnostic/Prognostic (29)
hsa_circ_0000826 / / Diagnostic/Therapeutic (30)
circ-FBXW7 / / Therapeutic (31)
circMTO1 / / Therapeutic/Prognostic (32)
circ_0002138 / / Diagnostic/Therapeutic (33)
hsa_circ_0002320 / / Diagnostic/Prognostic (34)
hsa_circ_0000711 / / Diagnostic/Prognostic (35)
circLMNB1 / / Therapeutic (36)
circFADS2 / / Therapeutic/Prognostic (37)
circUBAP2 miR-199a Negative Therapeutic (38)
hsa_circ_0044556 hsa-mir-214-3p Negative Diagnostic/Therapeutic/Prognostic (39)
circVAPA miR-125a Negative Therapeutic (40)
circHUWE1 miR-486 Negative Diagnostic/Therapeutic (41)
circMBOAT2 miR-519d-3p Negative Diagnostic/Prognostic (42)

References showed in Supplementary Material 3 .