Table 8.
Involvement of CR3 in additional interactions.
| Ligand | Site on CR3 | Site on ligand | Function | |
|---|---|---|---|---|
| Protein disulfide isomerase (extracellular) | – | Neutrophil recruitment, regulates fibrinogen binding and integrin clustering | (292) | |
| BAP31 | Binding was independent of αMI-domain | – | – | (293) |
| CD22 | Binds CD11b glycosylation, reduced upon neuramidase treatment | Not binding R77H (SLE) | (66) | |
| CD23 | Inhibited by FX, divalent cation dependent | – | ROS production, release of proinflammatory cytokines | (294) |
| IL-13Rα1 | β-propeller, CD11b leg | D1, D3, D2 | Cis ligation as negative feedback reduced foam cell formation |
(63) |
| Steel | – | – | Binding of monocytes to steel stents can lead to restenosis | (295) |