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. 2021 Apr 29;12:637825. doi: 10.3389/fphar.2021.637825

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Copyright © 2021 Yang, Li, Sun and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C791-0064 caused apoptosis of BRCA2-deficient cells. (A) Flow cytometry detection of apoptosis after 40 μM of C791-0064 treatment of shBRCA2-CDS BxPC3 cells for 48 h. (B) Quantification of apoptotic cell percentage (n = 3). (C) Western blot analysis of shBRCA2-CDS BxPC3 cells treated with different concentrations of C791-0064 for 48 h. (D,E) Immunofluorescence staining of γ-H2AX in shBRCA2-CDS BxPC3 and BxPC3 cells treated with 40 μM of C791-0064 for 24 h and its quantification for cells positive forγ-H2AX foci (n = 3). Error bars represent for SD.