Table 2.
Comparison of clinical baseline characteristics of APA-GI patients with different serum AFP levels.
| Characteristic | AFP-L | AFP-H | P value |
|---|---|---|---|
| Age(y), median(IQR) | 63.0 (52.0-72.0) | 63.0 (57.0-69.0) | 0.814 |
| Sex, Male/Female (Male%) | 73/35 (67.6) | 50/19 (72.5) | 0.492 |
| Primary site, n (%) | 0.596 | ||
| Stomach | 88 (81.5) | 59 (85.5) | |
| Large intestine | 17 (15.7) | 7 (10.1) | |
| Small intestine | 1 (0.9) | 2 (2.9) | |
| Esophagus | 1 (0.9) | 0 (0) | |
| Multiple primary sites | 1 (0.9) | 1 (1.4) | |
| Tumor size(cm), median(IQR) | 4.0 (3.0-5.0) | 5.0 (4.0-6.0) | 0.047 |
| Pathological type, n (%) | 0.022 | ||
| Adenocarcinoma | 83 (76.9) | 64 (92.8) | |
| Signet ring cell carcinoma | 17 (15.7) | 3 (4.3) | |
| Mucinous adenocarcinoma | 8 (7.4) | 2 (2.9) | |
| Differentiation, n (%) | 0.473 | ||
| Highly differentiated | 1 (0.9) | 2 (2.9) | |
| Moderately differentiated | 27 (25.0) | 16 (23.2) | |
| Poorly differentiated | 64 (59.3) | 45 (65.2) | |
| Default | 16 (14.8) | 6 (8.7) | |
| pT, n (%) | 0.524 | ||
| 1 | 7 (10.6) | 1 (3.2) | |
| 2 | 10 (15.2) | 2 (6.5) | |
| 3 | 8 (12.1) | 4 (12.9) | |
| 4 | 37 (56.1) | 22 (71.0) | |
| Default | 4 (6.1) | 2 (6.5) | |
| pN, n (%) | 0.643 | ||
| 0 | 12 (18.2) | 8 (25.8) | |
| 1 | 13 (19.7) | 4 (12.9) | |
| 2-3 | 33 (50.0) | 17 (54.8) | |
| Default | 8 (12.1) | 2 (6.5) | |
| TNM staging, n (%) | 0.009 | ||
| I-III | 51 (47.2) | 20 (29.0) | |
| IV | 54 (50.0) | 49 (71.0) | |
| Default | 3 (2.8) | 0 (0.0) | |
| Liver metastasis | <0.001 | ||
| Yes | 41 (38.0) | 53 (76.8) | |
| No | 67 (62.0) | 16 (23.2) | |
| Extrahepatic metastasis | 0.962 | ||
| Yes | 63 (58.3) | 40 (58.0) | |
| No | 45 (41.7) | 29 (42.1) | |
| Lymphatic or/and blood vessel invasion | 0.509 | ||
| Yes | 24 (36.4) | 15 (48.4) | |
| No | 28 (42.4) | 10 (32.3) | |
| Default | 14 (21.2) | 6 (19.4) | |
| Nerve invasion | 0.126 | ||
| Yes | 14 (21.2) | 12 (38.7) | |
| No | 38 (57.6) | 16 (51.6) | |
| Default | 14 (21.2) | 3 (9.7) | |
| Hepatoid Adenocarcinoma# | 0.006 | ||
| Yes | 16 (32.7) | 16 (66.7) | |
| No | 33 (67.3) | 8 (33.3) |
#
Considering the lack of pathological sample obtained from endoscopy, 73 surgical patients out of 100 patients receiving second pathological diagnosis were included.