Table 5.
Regression analysis for prognostic risk factors of APA-GI liver metastasis.
| Variable | Single factor | Multiple factors | ||
|---|---|---|---|---|
| HR(95%CI) | P-value | HR(95%CI0) | P-value | |
| Age, y | 0.023 | 0.193 | ||
| <60 | 1 | 1 | ||
| ≥60 | 1.72 (1.08–2.74) | 2.13 (0.68–6.65) | ||
| Sex | 0.021 | 0.123 | ||
| Male | 1 | 1 | ||
| Female | 0.55 (0.33–0.91) | 0.30 (0.07–1.38) | ||
| Primary site | 0.906 | |||
| Stomach | 1 | |||
| Large intestine | 0.89 (0.47–1.67) | |||
| Other | 0.86 (0.27–2.72) | |||
| Tumor size, cm | 0.010 | 0.231 | ||
| <5 | 1 | 1 | ||
| ≥5 | 3.47 (1.35–8.89) | 1.96 (0.65–5.90) | ||
| Pathological type | 0.101 | |||
| Adenocarcinoma | 1 | |||
| Signet ring cell carcinoma | 0.50 (0.23–1.09) | |||
| Mucinous adenocarcinoma | 0.45 (0.14–1.44) | |||
| Differentiation | 0.741 | |||
| Highly differentiated | 1 | |||
| Moderately differentiated | 1.34 (0.18–9.94) | |||
| Poorly differentiated | 1.10 (0.15–8.00) | |||
| pT | 0.113 | |||
| 1+2+3 | 1 | |||
| 4 | 1.26 (0.95–1.68) | |||
| pN | 0.603 | |||
| 0 | 1 | |||
| 1 | 1.65 (0.56–4.85) | |||
| 2+3 | 1.10 (0.45–2.73) | |||
| AFP, ng/ml | <0.001 | 0.012 | ||
| <200 | 1 | 1 | ||
| ≥200 | 2.24 (1.48–3.39) | 4.55 (1.39–14.87) | ||
| Lymphatic or/and blood vessel invasion | 0.013 | 0.354 | ||
| No | 1 | 1 | ||
| Yes | 3.31 (1.29–8.49) | 1.69 (0.56–5.14) | ||
| Nerve invasion | 0.277 | |||
| No | 1 | |||
| Yes | 1.6 (0.69–3.73) | |||
| Hepatoid Adenocarcinoma# | 0.029 | 0.615 | ||
| No | 1 | 1 | ||
| Yes | 2.60 (1.10–6.12) | 0.75 (0.35–2.27) | ||
| AFP IHC | 0.626 | |||
| Low expression | 1 | |||
| High expression | 1.22 (0.54–2.77) | |||
#
73 surgical patients out of 100 patients receiving second pathological diagnosis were included.