Fig 1.
A, Illustration of spectroscopic VOI in the central region in axial (left hemisphere) and coronal (right hemisphere) T2-weighted planscan images (left, upper and lower row). Sample spectra (TR/TE, 2000/140 ms; H2O-suppressed) of a healthy control (right, upper row) and patient IV/7 (Table 1) (right, lower row). B, 3D DTT (left) with intersection lines (yellow) shown at the level of FA/MD measurements (precentral gyrus, corona radiata, internal capsule, cerebral peduncles, pons, and pyramid). Fibers are projected onto axial FA (right/upper row, precentral gyrus) and MD maps (right/lower row, internal capsule) to allow a guided region-of-interest placement along the corticospinal tract. FA and MD statistics were additionally averaged on the CSTs as a whole to account for a region-independent analysis.