Table 2:

Correlation coefficients (r) between CC areas and ARWMC volume measured in standard space^*

Areas	Mean ARWMC (mL)	Mean CC Areas vs Mean ARWMC (mL) in the Brain (r)
		CC1	CC2	CC3	CC4	CC5	CC Total
Mean CC area (mm2)		179.3 ± 40.1	93.8 ± 25.2	90.8 ± 24.0	91.5 ± 27.3	184.0 ± 39.8	642.6 ± 135.4
ARWMC
Basal ganglia region	0.7 ± 0.9	−0.111	−0.077	0.039	−0.038	−0.162‡	−0.095
Frontal lobes	14.7 ± 15.4	−0.181§	−0.078	0.027	−0.07	−0.232§	−0.144†
Occipital lobes	1.2 ± 1.6	−0.181‡	−0.107	−0.004	−0.04	−0.223§	−0.146†
Parietal lobes	6.0 ± 7.4	−0.137†	−0.097	−0.004	−0.067	−0.201§	−0.132†
Temporal lobes	1.3 ± 1.9	−0.154‡	−0.157‡	−0.067	−0.104	−0.206§	−0.168‡
Total ARWMC	24.0 ± 25.0	−0.175‡	−0.076	0.035	−0.042	−0.230§	−0.134†

Note:—CC indicates corpus callosum; ARWMC, age-related white matter changes.

^*All CC and ARWMC values were normalized to the same head size. Values are mean CC areas and mean ARWMC volume (± SD), relative volume of the ARWMC volume assessed relative to the entire anatomic region, correlation coefficients (r), and significance level. In addition to the log-transformed ARWMC per brain region, we entered the following covariates: number of lacunes per brain region, number of infarcts, age, handedness, recruiting center, and ratings of sulcal and ventricular atrophy.

^†P < .01.

^‡P < .001.

^§P < .0001 (uncorrected).