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. 2021 Apr 22;6(8):e145936. doi: 10.1172/jci.insight.145936

Figure 5. Sgpl1-KO mice exhibit developmental delay, which is prevented by AAV-SPL.

Figure 5

Six neurodevelopmental milestones were scored in WT (n = 8), heterozygous (HET, n = 14), KO (n = 6), and AAV-SPL–treated KO (AAV, n = 3) pups. For A and D, unpaired t test with Bonferroni’s correction was applied. For B, C, and F, Mann-Whitney U with Bonferroni’s correction was applied. For KO vs. WT comparisons: (A, P < 0.0002); (B, P = 0.001); (C, P = 0.0008); (D, NSD; E, P = 0.0068); (F, P = 0.0056). There was NSD between AAV and WT/HET or WT and HET for A–F.