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. 2020 Jul 2;89(5):1222–1231. doi: 10.1038/s41390-020-1044-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Total duration (min), b frequency (number of episodes), and c average duration of episodes (min) as measured by parent-reported Barr diary. The respective sample sizes for the diurnal period at Baseline, Day 70, and Day 112 are Control: 78, 63, 61 and PDX/GOS: 75, 65, 61. The respective sample sizes for the nocturnal period at Baseline, Day 70, and Day 112 are Control: 77, 58, 47 and PDX/GOS: 70, 60, 52. Diurnal: Control, solid blue circles; PDX/GOS, solid purple squares and Nocturnal: Control, open blue circles; PDX/GOS, open purple squares.