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. 2020 Sep 12;28(5):442–454. doi: 10.1038/s41417-020-00226-z

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© The Author(s), under exclusive licence to Springer Nature America, Inc. 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Immunodeficient NMRI mice bearing subcutaneous PC3MM2 prostate tumors were injected intravenously with TILT-123 previously incubated with or without human lymphocytes or erythrocytes (500 VP/cell) in the presence of Ad5/3-specific antiserum. Negative mock control received PBS. After 3 days post treatments, the mice were euthanized and tumors (a), livers (b), spleen (c), lungs (d), and serum (e) were collected and snap-frozen to detect adenovirus Ad5/3 genomes through qPCR. Viral copy number was normalized against amount of genomic DNA in the sample, determined by the expression level of human β-actin (for tumors) and mouse β-actin (for murine samples). Copy number ratios in tumors vs. livers were calculated to evaluate the distribution of the virus (f). Data are presented as mean. RBC: erythrocytes; Lympho: lymphocytes. *P < 0.05 by two tailed post hoc Dunn’s test adjusted by Holm multiple testing correction method.