Table 1.

Classification of transcriptome

Transcriptome Study/Year	Properties	Classifications					References
Collisson et al. 2012		Classical Type	Quasi-Mesenchymal type	Exocrine type			[35]
	Biomarkers	GATA6 KRAS	Low or no expression of GATA6	ELA3A/ CFTR
	Pharmacologically sensitive	Gemcitabine (low) Erlotinib (high)	Gemcitabine (high)
	Prediction	Better survival	Worse overall survival
Moffitt et al 2015		Stroma related		Tumor related			[31]
		Normal	Activated	Classical	Basal
	Biomarkers	ACTA2, DES, VIM	ITGAM, CCL13, CCL18, FAP, SPARC, WNT2, MMP9, MMP11, WNT5a	GATA6	No expression of GATA6
	Prediction	Good	Worst	Best	Worst
	Pharmacologically sensitive			5-FU (high) Gemcitabine (low)	5-FU (low)
Bailey et al		Squamous subtype	Pancreatic progenitor	ADEX	Immunogenic		[32]
	Biomarkers	GATA6 ↓and TP63↑	PDX1, FOXA2, FOXA3	MIST1, NR5A2	Immune cells (CD4+, CD8+), Check points (CTLA4, PD1)
	Predictive	Poor	Good	Good	Good
Puleo et al		Pure basal like	Pure/ immune classic	Stroma activated	Desmoplastic		[33]
	Biomarkers	GATA6↓, CDKN2A/ TP53	GATA ↑, CTLA4, immune cells (T & B cells)	α-SMA, FAP, SPARC	Stromal components
	Predictive	Poor	Good	Average	Average
Chang-seng-Yue et al		Classical	Basal	Hybrid			[34]
	Biomarkers	GATA4 ↑, GATA6↑	GATA6↓	GATA6 ↓↑
	Pharmacologically sensitive	Gemcitabine(low) mFOLFIRINOX (high)	mFOLFIRINOX (low) gemcitabine (high)
	Prediction	Good	Poor	Average