Table 1.
Serum gadolinium (Gd) concentrations at various time points following intra-articular injection
| ng Gd/ml serum, (median and range) | ||||||
|---|---|---|---|---|---|---|
| Group | 0 h | 1 h | 3 h | 6 h | 24 h | 72 h |
| Saline |
0.01 (0.00–0.09) |
0.02 (0.00–0.04) |
0.02 (0.00–0.02) |
0.09 (0.00–0.12) |
0.67 (0.00–1.62) |
0.59 (0.38–3.41) |
| High-dose gadodiamide |
0.09 (0.03–0.58) |
34,696 (32742–48,306) |
1158 (1075–2555) |
78.76 (36.78–120) |
25.26 (16.54–27.51) |
14.43 (7.69–15.75) |
| High-dose gadobutrol |
0.01 (0.01–0.05) |
17,621 (14354–46,869) |
1723 (278–2000) |
44.92 (24.26–65.55) |
16.5 (10.32–19.36) |
6.67 (4.53–9.38) |
| Low-dose gadodiamide |
0.49 (0.02–1.13) |
566 (374–595) |
15.59 (13.03–16.65) |
1.66 (1.62–1.86) |
0.51 (0.49–0.56) |
0.19 (0.17–0.21) |
| Low dose gadobutrol |
0.55 (0.09–1.03) |
883 (778–898) |
25.35 (21.08–32.71) |
1.34 (1.15–2.03) |
0.61 (0.41–0.87) |
0.31 (0.21–0.34) |