Table 2.
Urine gadolinium (Gd) concentrations at various time points following intra-articular injection
| ng Gd/ml urine, (median and range) | ||||||
|---|---|---|---|---|---|---|
| Group | 0 h | 1 h | 3 h | 6 h | 24 h | 72 h |
| Saline |
21.62 (0.21–29.64) |
1.30 (0.35–17.07) |
0.23 (0.10–0.37) |
0.24 (0.15–0.30) |
1.93 (0.08–4.92) |
6.16 (4.89–36.96) |
| High-dose gadodiamide* |
0.12 (0.10–0.20) |
1,854,114 (689986–3,018,242) |
1,124,178 (0) |
181,373 (0) |
2578 (1099–8489) |
1087 (424–1168) |
| High-dose gadobutrol |
0.55 (0.15–0.86) |
23,820,000 (8670740–24,000,000) |
1,229,390 (803300–16,653,400) |
88,892 (19029–129,453) |
4344 (2553–6787) |
2167 (696–2491) |
| Low-dose gadodiamide |
2.25 (0.48–25.68) |
67,346 (61441–272,132) |
45,552 (15071–76,032) |
2711 (2233–3993) |
98.54 (14.26–158) |
95.14 (23.45–448) |
| Low-dose gadobutrol |
45.56 (1.57–65.69) |
141,136 (82913–227,951) |
83,833 (9477–102,339) |
6913 (3063–9801) |
627 (48.69–2075) |
28.68 (25.26–73.75) |
*Urine was unable to be collected from two of the three rats in this group at the 3 h and 6 h time points