Figure 3.

Effect of Ex-4 treatment on cue- and drug-induced reinstatement. A) Saccharin intake on test day. Mean ± SEM number of licks/5min of 0.15% saccharin for rats in the saccharin-saline controls, small suppressors and large suppressors groups treated with Veh or Ex-4 on cue- and drug-induced reinstatement test 1. B) Latency to 1^st contact. Mean ± SEM log latency to 1^st contact with the active spout for saccharin-saline, small and large suppressor groups treated with Veh or Ex-4. C) Cue-induced seeking. Mean ± SEM number active (left) and inactive (right) spout contacts/60min for saccharin-saline, small and large suppressors groups treated with Veh or Ex-4. D) Extinction. Mean ± SEM number of contacts with active and inactive spouts/6h of extinction for saccharin-saline (top panel), small suppressors (middle panel) and large suppressors (bottom panel) treated with Veh or Ex-4. E) Drug-induced reinstatement test 1. Mean ± SEM number of active (left) and inactive (right) spouts contacts during the 60 minutes after the drug prime for saccharin-saline, small and large suppressors groups treated with Veh or Ex-4 six hours prior to the drug prime (Sac-sal-veh: n=7, Sac-sal-Ex-4: n=8, SS-veh: n=9, SS-Ex-4: n=8, LS-veh: n=7, LS-Ex-4: n=9). *Significant difference between groups. #Significant difference between Veh and Ex-4 treatment. Different letters indicate significant differences.