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. Author manuscript; available in PMC: 2022 May 10.
Published in final edited form as: Curr Biol. 2021 Mar 10;31(9):1903–1917.e6. doi: 10.1016/j.cub.2021.02.015

Figure 7. Local accumulation of stiff ECM constrains the angle of bifurcation of simulated TEBs.

Figure 7.

A) Geometry and mesh of FEM-based model of bifurcating TEB. B) Different time steps during a simulated bifurcation of a TEB. C) Traces of the epithelial geometry as a function of simulation time. The final time point of simulations, traces of the final epithelial geometry, and bifurcation angles for simulations with D) varying ECM accumulation on the flanks of the TEB, E) varying ECM accumulation at the leading edge of the TEB, and F) varying rates of ECM accumulation at the leading edge of the TEB. See also Figure S6 and Videos S1–S8.