Figure 3.

A screenshot of the ADDRESS online database interface. The interface contains three parts. The view switching banner is the top under the database logo, switched to “Browse by structure” page 1 in this screenshot. A JSmol structure applet is at lower left, displaying PDB structure 1a7a Chain A for human Adenosylhomocysteinase protein AHCY (yellow cartoon) in complex with the NAD and ADC ligands (magenta sticks) and mutation sites (red and blue lines of pathogenic and benign mutations, respectively). The main table at the lower right displays all entries sorted by PDB IDs, where 1a7a Chain A for AHCY is currently selected. At the upper right corner of the database interface is the “Search” button, with which users can search database entries by protein names, PDB IDs, mutations, diseases, and structural features (e.g., contact numbers and free energy changes).