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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Hypertension. 2021 May 3;77(6):2117–2126. doi: 10.1161/HYPERTENSIONAHA.120.16911

Figure 1. Endothelial Mineralocorticoid Receptor Knockout (EC-MR-KO) Improves Obesity-Induced Microvascular Vasodilation Impairment.

Figure 1.

Female EC-MR intact (EC-MR-WT) and EC-MR-KO mice were fed normal (lean) or high fat diet (obese) for 20 weeks and endothelial-dependent vasodilation was measured ex vivo using acetylcholine (ACh). (A) In lean females, there is no difference in vasodilation comparing EC-MR-WT (closed circles) versus EC-MR-KO (open circles). (B) In obese females, vasodilation is improved in EC-MR-KO versus EC-MR-intact. *p<0.05, ***p<0.001, 2-way repeated measures ANOVA, Bonferroni post hoc.