Figure 1.

Expression profiles of genes containing T1D-associated coding variants. (a) Heatmap depicting relative gene expression by organ. Rows are organ classifications utilized in The Human Protein Atlas (HPA), and columns are individual genes containing T1D-associated coding variants. Depicted are the consensus normalized expression (NX) values summarized from HPA, Genotype-Tissue Expression (GTEx), and Functional Annotation of Mammalian Genomes 5 (FANTOM5) transcriptomics datasets.⁹⁰ (b) Heatmap of gene expression within immune cell subsets. Data are population averaged gene expression from the Human Cell Atlas Census of Immune Cells, an ultra-low-input (ULI) RNA-Seq dataset.⁹¹ Blue represents high expression, while white represents low expression levels. Cells indicated as natural killer (NK), mucosal-associated invariant T (MAIT), regulatory T cell (Treg), and dendritic cell (DC).