Table 5.
Predictive factors for false negative MICRA biopsies (n = 78)
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P - value | OR | 95% CI | P - value | |
| Imaging features pre-NST | ||||||
| Tumor size (mm) | 0.98 | 0.95–1.00 | 0.066 | 0.98 | 0.94–1.01 | 0.23 |
| Multifocal | 0.36 | 0.12–1.11 | 0.074 | |||
| Non-mass | 0.80 | 0.28–2.28 | 0.67 | |||
| Calcifications | 1.02 | 0.40–2.60 | 0.96 | |||
| Histology pre-NST | ||||||
| Ductal | 1 | |||||
| Lobular | 0.64 | 0.15–2.72 | 0.55 | |||
| Other | 0.00 | 0.00–Inf. | 0.99 | |||
| HR ≥ 10% pre-NST | ||||||
| Positive | 4.25 | 1.58–11.48 | 0.0043 | 4.55 | 0.95–21.73 | 0.058 |
| Subtype pre-NST | ||||||
| HR +/HER2 - | 1 | |||||
| HR +/HER2 + | 1.35 | 0.37–5.02 | 0.65 | |||
| HR -/HER2 + | 8.12 | 1.31–50.21 | 0.024 | |||
| triple-negative | 3.97 | 1.21–12.99 | 0.023 | |||
| Radiological response | ||||||
| Partial | 1 | |||||
| Complete | 5.98 | 1.59–22.46 | 0.008 | 9.81 | 1.72–55.89 | 0.01 |
| Pathology post-NST | ||||||
| Tumor size (mm) | 0.88 | 0.81–0.95 | 0.0006 | 0.93 | 0.87–1.00 | 0.051 |
| DCIS or invasive carcinoma | ||||||
| No DCIS | 1 | |||||
| DCIS and invasive | 0.28 | 0.08–0.97 | 0.044 | 0.51 | 0.12–2.11 | 0.35 |
| DCIS only | 4.26 | 0.78–23.44 | 0.095 | 2.39 | 0.23–24.37 | 0.46 |
Univariable and multivariable logistic regression. HR, hormone receptor expression; NST, neoadjuvant systemic therapy. All baseline characteristics were assessed before administration of neoadjuvant systemic therapy. Calcifications were assessed on mammography, other imaging features were assessed on MRI