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. 2021 May 13;11:10299. doi: 10.1038/s41598-021-89786-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Representative histograms of SIGLEC1 fluorescence on CD14^high monocytes, FMO: fluorescence minus one control. (b) Cross-sectional analysis of SIGLEC1 expression on CD14^high monocytes of 31 healthy controls, 86 MS patients and 41 NMOSD patients. If multiple samples of the same individual were analysed, the mean of the measurements is displayed. (c) Longitudinal analysis of SIGLEC1 expression of 52 individuals with up to five measurements. (d) Comparison of SIGLEC1 expression in MS patients, receiving no immunomodulatory treatment (n = 24), interferon beta (n = 13) or a non-interferon treatment (n = 49). Treatment with interferon with significantly associated with higher levels of SIGLEC1 expression: Kruskal–Wallis test with Dunn’s correction, **p < 0.01, ****p < 0.0001. (e) Comparison of SIGLEC1 expression in patients with RRMS (n = 63), SPMS (n = 15) and PPMS (n = 5). Red symbols indicate interferon treatment. (f) Scatter plot of the EDSS disability score against SIGLEC1 expression, no significant correlation was detected.