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. 2021 May 13;11:10228. doi: 10.1038/s41598-021-89478-9

Figure 6.

Figure 6

AP changes in response to the environmental chemical BPA in hiPSC-CMLP with 5% hCF microtissues. (A) Representative Vm traces from 0, 1, 10, 100, and 1000 nM BPA stimulated at 0.5 Hz. (B) AP metric color map shows a trend of APD shortening (blue colors) at higher doses and a minority of microtissues having a biphasic effect with increases (red–orange) in stimΔ and APD metrics at 1 nM. Key to the panel is as described in Fig. 5B. (C) AP parameter summary bar graph. Values are means ± SD. See Supplemental Table 1 (bottom) for p values. (D-G) Cumulative probability plots for rise time (D), APD80 (E), APDMxR (F), and APDtri (G).