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. 2021 May 13;11:10228. doi: 10.1038/s41598-021-89478-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Characteristic AP metric changes induced by Ranolazine and BPA. The color maps of mean difference AP metrics by ranolazine (A) and BPA (B). The mean differences of AP metrics were normalized by each metric’s standard deviation in control (σ_CTR). Statistically significant increase and decrease (p < 0.05, paired t-test) are presented by red and blue color, respectively. (C,D) APD_tri versus APD_MxR plots in response to increasing concentrations of ranolazine (C) and BPA (D; * p < 0.01).