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. 2021 May 13;7:103. doi: 10.1038/s41420-021-00486-0

Fig. 1. HBO increases tumour volume but promotes chemosensitization.

Fig. 1

A Schematic process of the in vivo study with or without HBO treatment. B–D MRI showed that the tumour volume was larger and the tumour weight was higher in the group under HBO conditions than in the control group without HBO treatment in the absence of TMZ. However, after treatment with the same dose of TMZ (2 mg/kg), the tumour volume decreased and the tumour weight was decreased in the group exposed to HBO compared with the control group. E, F In the absence of TMZ, the survival time became shorter after HBO exposure (median survival time of the HBO treatment group vs control group = 22 vs 26 days). However, after TMZ treatment (2 mg/kg), the group that was exposed to HBO had a much longer survival time than the control group without HBO treatment (median survival of the HBO treatment group vs control group = 37 days vs 30.5 days). G The cells exposed to HBO had a higher proliferation rate than the control cells without HBO treatment in the absence of TMZ, but the cells exposed to HBO had a lower growth trend than the control cells without HBO following TMZ treatment (400 μM). H The HBO treatment group had a higher apoptosis rate than the control group with the same TMZ treatment (400 μM). The P value was determined by an independent samples t-test, and the survival time was analysed by the log-rank test.