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. 2021 May 13;11:10202. doi: 10.1038/s41598-021-89450-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic diagram of the shelterin and CST complexes bound to telomeric DNA. TRF1 telomeric repeat binding factor 1; TRF2 telomeric repeat binding factor 2; TIN2 TRF1 interacting nuclear factor 2; TPP1 protein encoded by adrenocortical dysplasia homolog (ACD) gene; POT1 protection of telomerase; CTC1 conserved telomere maintenance component 1; STN1 suppressor of CDC thirteen homolog; TEN1 telomere length regulation protein TEN1 homolog.